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However, although weight loss was observed in some studies, it did not occur in all studies (2)

These factors rarely act as the sole cause of pain, but they can maintain nerve irritation , increase pain sensitivity , delay recovery, and reduce the effectiveness of otherwise appropriate treatment

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Peng L, Yuan Z, Li Y, Ling H, Izumi V, Fang B, Fukasawa K, Koomen J, Chen J, Seto E (2015) Ubiquitinated sirtuin 1 (SIRT1) function is modulated during DNA damage-induced cell death and survival

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